Calcium Hydrogen Phosphate Dihydrate

    • Product Name: Calcium Hydrogen Phosphate Dihydrate
    • Chemical Name (IUPAC): Calcium hydrogen phosphate dihydrate
    • CAS No.: 7789-77-7
    • Chemical Formula: CaHPO4·2H2O
    • Form/Physical State: Solid
    • Factroy Site: Lingwu, Yinchuan, Ningxia, China
    • Price Inquiry: sales2@liwei-chem.com
    • Manufacturer: Anhui Liwei Chemical Co.,Limited
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    Specifications

    HS Code

    820544

    Chemical Name Calcium Hydrogen Phosphate Dihydrate
    Chemical Formula CaHPO4·2H2O
    Molar Mass 172.09 g/mol
    Appearance White crystalline powder
    Solubility In Water Slightly soluble
    Melting Point Decomposes above 203°C
    Density 2.32 g/cm3
    Cas Number 7789-77-7
    Ph Value Between 7 and 9 (1% suspension)
    Uses Food additive, fertilizer, pharmaceuticals
    Stability Stable under normal conditions

    As an accredited Calcium Hydrogen Phosphate Dihydrate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, sealed HDPE container labeled "Calcium Hydrogen Phosphate Dihydrate, 500g," with hazard symbols, batch number, and storage instructions visible.
    Container Loading (20′ FCL) 20′ FCL can load approximately 27 metric tons of Calcium Hydrogen Phosphate Dihydrate, typically packed in 25 kg or 50 kg bags.
    Shipping Calcium Hydrogen Phosphate Dihydrate should be shipped in tightly sealed containers, protected from moisture and incompatible substances. It is non-hazardous but should be handled with care, following standard chemical safety protocols. Store in a cool, dry place, and ensure packaging is clearly labeled to prevent contamination and accidental misuse during transport.
    Storage Calcium Hydrogen Phosphate Dihydrate should be stored in a tightly closed container, in a cool, dry, and well-ventilated area. Keep away from moisture, incompatible substances (such as strong acids), and sources of ignition. Avoid temperature extremes and protect from physical damage. Store at room temperature and ensure the storage area is clearly labeled for chemical safety and compliance.
    Shelf Life Calcium Hydrogen Phosphate Dihydrate typically has a shelf life of 3-5 years when stored in dry, tightly sealed containers at room temperature.
    Application of Calcium Hydrogen Phosphate Dihydrate

    Applications of Calcium Hydrogen Phosphate Dihydrate in Industrial Manufacturing

    Calcium hydrogen phosphate dihydrate is widely adopted in several advanced industrial sectors. As an established producer, we supply high-purity material precisely engineered for strict downstream requirements. Below, we outline key application areas in real manufacturing, directly reflecting practical processing, regulatory, and end-product demands.

    1. Pharmaceutical Tablet and Capsule Manufacturing

    Pharmaceutical companies incorporate calcium hydrogen phosphate dihydrate as a direct compression excipient in the production of tablets and hard-filled capsules. Manufacturers prefer this material as a filler and diluent, owing to its controlled particle size, low reactivity, and excellent flow properties. Quality assurance teams ensure all supplied batches meet pharmacopeial criteria, supporting reliable mechanical strength and consistent disintegration behavior in oral solid dosage forms. The formulation specialist adjusts ratios to accommodate different active pharmaceutical ingredient (API) loads and tablet sizes, securing uniformity and regulatory compliance throughout the downstream process.

    Industry compliance standards

    • USP–NF Monograph for Dibasic Calcium Phosphate Dihydrate
    • Ph. Eur. (European Pharmacopoeia) 10.0: "Calcii hydrogenophosphas dihydricus"
    • ChP (Chinese Pharmacopoeia): Dibasic Calcium Phosphate Dihydrate standard
    • Good Manufacturing Practice (GMP) requirements for pharmaceutical excipients

    Typical usage ratio

    • Filler in tablet core blends: 10%–65% w/w, adjusted for API load and compression profile
    • Capsule diluent: 15%–50% w/w, modulated for flow and fill consistency

    Downstream process integration

    • Blending with APIs and other excipients in high-shear or bin blenders
    • Direct feeding into rotary tableting machines or capsule fillers
    • QC for particle size and bulk density before granulation or compaction
    • In-process control ensures blend uniformity before final tablet or capsule compression

    Final product types

    • Immediate-release compressed tablets
    • Modified-release and chewable tablets
    • Hard gelatin and HPMC capsule formulations
    • Multivitamin and mineral supplement solids

    2. Food and Beverage Fortification

    Food and beverage processors formulate with calcium hydrogen phosphate dihydrate to enhance nutritional profiles of finished goods with bioavailable calcium and phosphorus. The material features high batch-to-batch consistency, tailored for fortified dairy substitutes, flour premixes, reconstituted beverages, and bakery items. Plant quality assurance adapts ratios according to regional food additive guidelines, targeting both mineral enrichment and pH buffering. Product technologists integrate it during dry mixing, ensuring homogenous dispersal and reliable mineral content in every batch.

    Industry compliance standards

    • FCC (Food Chemicals Codex) Specifications for Calcium Hydrogen Phosphate
    • EU Food Additive E341(ii) Regulation (EC) No 1333/2008
    • FDA 21 CFR §184.1212 (GRAS affirmation for direct addition to food)
    • HACCP and FSSC 22000 certified food safety management

    Typical usage ratio

    • Calcium fortification in flour: 0.5%–1.5% (by product weight)
    • Beverage fortification: 0.05%–0.3%, adjusted for solubility and labeling limits
    • Baked goods and infant cereal: 0.2%–1.0%, depending on regulatory maximums

    Downstream process integration

    • Addition during initial dry ingredient blending of flour or baking pre-mixes
    • Dissolution or pre-slurry in beverage and liquid nutritional product preparation
    • Screening to ensure deagglomeration before dough mixing or batter formation
    • Routine sampling to validate mineral content versus nutritional claims

    Final product types

    • Enriched wheat and maize flour
    • Powdered and UHT reconstituted beverages
    • Breads, biscuits, and breakfast cereals
    • Infant formula and growing-up milks

    3. Animal Feed and Premix Production

    Agribusinesses utilize this material as a major macro-mineral source in compound feeds and veterinary premix formulations. Calcium and phosphorus are vital for the optimal skeletal and metabolic health of livestock, poultry, and aquaculture species. Manufacturers precisely weigh feed-grade calcium hydrogen phosphate dihydrate, blending with other macro- and trace-minerals to maintain correct nutritional ratios as mandated by regional livestock feeding codes. Quality control tracks batch traceability and verifies physical characteristics before incorporation into pelleting, mash, or extrusion processes.

    Industry compliance standards

    • Association of American Feed Control Officials (AAFCO) Feed Ingredient Definition 6.63
    • EU Register of Feed Additives Regulation (EC) No 1831/2003 (Category: Nutritional Additives, E341(ii))
    • ISO 22000 feed safety management systems
    • FAMI-QS certification for specialty feed ingredient manufacturers

    Typical usage ratio

    • Poultry and layer feed: 1.5%–3%, adjusted for diet formulation and species
    • Ruminant and swine premix: 0.8%–2.5% of total ration
    • Aquafeed premix: 0.2%–1.0%, influenced by target species and water stability requirements

    Downstream process integration

    • Primary dosage during base feed mixing or premix blending
    • Homogenization in ribbon blenders or paddle mixers for uniform mineral distribution
    • Pellet mill or extrusion integration at high throughput speeds
    • Final product QC for calcium and phosphorus concentrations as per feed formulation specs

    Final product types

    • Compound animal feeds for poultry, swine, dairy cattle, and sheep
    • Custom mineral premixes for livestock farms
    • Extruded and pelletized aquafeeds
    • Pet nutritional supplements (mineral tablets, powders)

    4. Dental Care Formulations

    Oral care manufacturers use calcium hydrogen phosphate dihydrate as a gentle abrasive and calcium donor in toothpaste and dental powder products. The material’s controlled particle structure delivers thorough yet low-abrasion cleaning for enamel and dentin, while supplying bioavailable minerals. The formulation chemist blends it with other polishing agents under stringent cosmetic and dental health standards, with particle size distribution closely monitored for mouthfeel and safety. Its performance supports anti-caries benefits and whitening without excessive wear, making it a favored raw material in both adult and children’s formulations.

    Industry compliance standards

    • ISO 11609:2017 (Dentistry – Dentifrices – Requirements, test methods, and marking)
    • FDA 21 CFR §355: Oral Health Care Drug Products
    • EU Cosmetics Regulation (EC) No 1223/2009 (where applicable in non-drug products)
    • National dental association ingredient approvals as required (e.g., ADA)

    Typical usage ratio

    • Abrasive and remineralization agent in toothpaste: 5%–20% by total weight
    • Dental powders: up to 40%, based on desired cleaning power and texture

    Downstream process integration

    • Incorporation during primary mixing with humectants, surfactants, and flavors
    • High-shear homogenization to disperse abrasives evenly
    • Sieve analysis for uniform particle size before tube or jar filling
    • Quality checks for abrasive index and microbiological safety

    Final product types

    • Whitening and anti-cavity toothpaste
    • Children’s dental gels with low-abrasion profiles
    • Professional-grade prophylaxis and polishing powders
    • Tooth cleaning tablets

    5. Industrial Water Treatment and Boiler Scale Control

    Operators of water treatment facilities and steam boiler plants deploy calcium hydrogen phosphate dihydrate for precipitation control and neutralization in closed-loop and open-loop systems. The carefully regulated addition helps maintain target calcium-to-phosphate ratios, minimizing scaling by adjusting water hardness and phosphate activity. Process engineers meter the material at points of maximum turbulent mixing, factoring in feedwater composition and system volume to optimize dosage. Compliance with industrial water safety guidelines is essential, and on-site testing verifies residual levels and treatment efficacy in real time.

    Industry compliance standards

    • ASTM D 4519-16: Standard Practice for Industrial Water Conditioning
    • EU Drinking Water Directive (if included in potable water applications)
    • Boiler and cooling water guidelines by ASME and NACE International
    • Local water effluent and environmental regulations

    Typical usage ratio

    • Scale inhibitor and neutralizer: 2–30 mg/L, adjusted for water hardness and system kinetics

    Downstream process integration

    • Continuous or batch dosing to feedwater in mixing tanks
    • Automated control based on conductivity or hardness probe feedback
    • Routine checks of calcium, phosphate residuals, and scaling indices
    • Sludge separation and removal in systems with high mineral cycles

    Final product types

    • Conditioned boiler feedwater
    • Cooling water treatment chemicals
    • Precipitation control packages for industrial recycling
    • Specialty water treatment service contracts

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    Certification & Compliance
    More Introduction

    Calcium Hydrogen Phosphate Dihydrate: A Manufacturer’s Perspective

    Understanding the Essentials of Calcium Hydrogen Phosphate Dihydrate

    Calcium hydrogen phosphate dihydrate, also known as dicalcium phosphate dihydrate or DCPD, finds daily use across agriculture, food, pharmaceutical, and technical industries. By producing this compound at the manufacturing level, we've noticed how end-use intertwines with every processing step, from precision in raw material control to monitoring particle size as the final powder leaves the plant. For many years, our teams have worked with this material, both in its rawest forms and as a finished white crystalline powder, giving us a close view of what makes it unique.

    In manufacturing, starting materials set the tone. The reaction between calcium hydroxide and phosphoric acid produces dicalcium phosphate dihydrate with a predictable stoichiometry, ensuring a stable output of CaHPO4·2H2O and a predictable calcium content. The structured two-water molecule form distinguishes it from the anhydrous (DCPA) or monohydrate versions. Once the precipitation reaction reaches completion, careful washing and filtration drive off unwanted ions, while retaining sufficient crystalline integrity. This matters for downstream users, especially food or feed processors, who expect clean, low-solubility mineral powders that dissolve at controlled rates when stirred into their own mixtures.

    Physical and Chemical Properties Based on Production Handling

    On the production floor, the dihydrate form always stands apart for its easy processing and free-flowing behavior. Our ranges typically show a calcium assay near 23% and phosphorus content about 18%, results we track lot by lot. Bulk density sits around 0.8-1.0 g/cm3 for most batches; finer grades do flow a little less, but they handle gentle conveying well. Tight moisture control prevents unwanted caking in food manufacturing or feed plants. Since water molecules remain part of its structure, quick exposure to ambient air never risks the dustiness common to some anhydrous powders.

    Color uniformity comes from refined synthesis conditions. Proper pH control and slow-temperature precipitation keep color and trace metals low. Iron and heavy metal residues can catch up in finished powder quality when raw material grades slip. Meeting consistent specifications has a real impact. For example, the pharmaceutical grade sticks to strict limits on heavy metals and microbiology, while animal feed customers tolerate broader composition ranges. Working directly with laboratory and quality control staff, we see how small tweaks in the process—feed ratios, wash cycles, drying temperature—either maintain or compromise the purity of each batch. Having full control over production allows us to deliver powders for tabletting, granulation, and direct inclusion in bakery, cereal, or animal supplement blends.

    Applications Seen Through the Manufacturer’s Lens

    One clear lesson over the years: calcium hydrogen phosphate dihydrate’s value depends on clean trace mineral delivery. Within feed manufacturing, our DCPD acts both as a source of digestible calcium and phosphorus and as a binder or carrier for vitamins. Grain premixes remain the biggest outlet by volume—the bland, neutral taste and measured solubility let users control fortification rates without clumping or off-flavors. The nutritional role becomes even clearer at the farm level: livestock, particularly pigs and poultry, require direct supplementation, and feed makers count on guaranteed minimum levels for every bag filled.

    Moving to food processing, larger buyers include cereal, flour, and biscuit plants. As a leavening component, DCPD reacts gently with baking soda, providing a slow CO2 release in double-acting baking powders. Bakers and food technologists never want bitterness or excessive aftertaste, and this calcium phosphate’s low solubility prevents over-leavening or odd textures, especially in calcium-enriched products. Because it avoids absorbing strange odors and carries virtually no color, it blends invisibly into milled flour or powdered sugar bases.

    We always notice an uptick in orders before the production season for calcium-fortified beverages and nutrition bars. Food standards continue to tighten, with buyers sending in more stringent specifications for heavy metal residues, physical fineness, and microbiological cleanliness. The plant adapts by adjusting screening and handling protocols, keeping the process responsive so the finished powder qualifies for food-grade certifications by both local and international audit teams.

    Pharmaceutical industries present a unique relationship. Tabletting formulations call for dicalcium phosphate as an excipient, where compressibility and chemical stability rank equally alongside purity. Tabletting machines show clear preferences for specific particle size distributions. Our production teams run dedicated lines to eliminate cross-contamination, investing heavily in regular cleaning, intrinsic batch traceability, and particle size reduction technologies. End results: reliably compressible granules, low moisture uptake, low friability, and no detectable microorganisms.

    For technical markets, fertilizer blenders look to this material for steady phosphorus release and environment-friendly composition. Unlike many water-soluble phosphates, this grade resists quick leaching, supporting targeted plant growth without contributing to run-off or waterway contamination. Blenders and granule makers customizing soil amendments count on our product’s steady physical and chemical fingerprint. We’ve noticed increased interest from greenhouse growers as regulations curb excessive phosphate use.

    Differences from Other Calcium Phosphates and Form Variations

    Users often ask us how calcium hydrogen phosphate dihydrate compares with its relatives. The differences matter in real-world factory use, especially at high throughput.

    The major alternative, monocalcium phosphate, offers high water solubility and a more acidic pH, making it the fertilizer industry’s choice for superphosphates. Plants absorb its nutrients faster, but in food and feed, this stronger acidity sometimes presents challenges. Dicalcium phosphate dihydrate, with its neutral pH, avoids most handling, equipment, and regulatory headaches linked to acidic flux or metal corrosion. In large-scale biscuit or flour blending, we see far fewer issues with taste—acidic phosphates rarely blend as easily in sugar-based or dairy-powder formulations.

    Comparing with the anhydrous form—dicalcium phosphate anhydrous (DCPA)—the dihydrate stands out for easier processability. DCPA flows more dustily, handles with increased static, and picks up ambient humidity quickly, turning lumpy if not stored tightly. The dihydrate, on the other hand, responds better to pneumatic transfer and extended storage. Over dozens of customer visits, operational managers confirm that our dihydrate-based lines show less downtime from caking or arching inside hoppers.

    In terms of synthetic tricalcium phosphate, there’s a clear difference in calcium concentration. Tricalcium phosphate offers a higher Ca content, but less phosphorus—from a manufacturer's viewpoint, it fails as a direct phosphorus supplement or binder in feed and food systems. Handling tricalcium phosphate also demands tighter dust control, with fines often necessitating regular machine cleaning.

    Our customers also ask about natural (bone-derived) versus synthetic (precipitated) calcium phosphates. We rely on a fully synthetic process, so the risk of animal-borne contaminants never enters the chain. This reassures feed and food customers needing non-animal origin declarations for kosher, halal, or vegan labeling. Synthetic precipitation enables us to tailor particle size, purity, and color more tightly—a key advantage compared to the variable, off-color powders sometimes seen in bone-sourced grades.

    Process Controls, Quality, and Regulatory Pressures

    From a manufacturer’s side, the community never stands still. Demands climb for consistent, traceable material that complies with both local codes and global import rules. We work with internal and outside labs to verify purity, elemental content, physical properties, and compliance documentation on every run. The focus starts with phosphate rock selection, because upstream contamination with fluoride, heavy metals, or radioisotopes can crop up in the finished batch. Only with fully closed, filtered processing do we achieve the levels suitable for food and pharma codes: arsenic, chromium, cadmium, and lead all come in below detection on validated runs.

    Manufacturing teams track product quality at every step. Preparing solutions, controlling reaction temperature, following strict residence times in reactors, and using high-grade filters all lead to uncontaminated, uniformly crystalline powder. Shortcuts here create end-user headaches. In one example, a missed quality check led to powder with slightly elevated iron—suitable for feed blending but instantly rejected by a dairy ingredient facility. Regulatory auditors now demand uniform documentation: we routinely maintain digital records of heavy metal assays, microbiological counts, and supply chain integrity, uploaded batch by batch, so buyers anywhere in the world can check materials before deployment.

    On-site audits have grown, especially from international customers. Visits now routinely include plant hygiene checks, allergen control, and microbial risk management strategies. Every adjustment in humidification, air handling, or cleaning cycles aims at a clear outcome—meeting not just today’s food safety goals, but tomorrow’s regulations as well.

    Packaging, Traceability, and Shelf Life Challenges

    These powders ship anywhere from 25-kilogram bags to multi-tonne tanker trucks. Feed and fertilizer users want large packs, low cost, and rapid delivery. Food and pharma makers require bags with multi-layer barriers, food-contact approvals, and clearly traceable labeling. We see how even small flaws in bagging—unsealed liners or rough handling during storage—lead to product caking, dust escape, or moisture ingress. In response, our packing lines use dedicated systems, sealed conveyors, and barcode-based tracking, calling up every batch’s process history within seconds.

    Customers ask about shelf life. Given its low water activity and high chemical stability, calcium hydrogen phosphate dihydrate routinely holds up for two or more years if handled correctly and stored in dry, shaded, unheated spaces. Moisture uptake and caking represent the major deteriorating factors; proper packaging stands as the most decisive element for long shelf life. Repackaging or splitting bulk shipments requires careful attention: even a day of exposure in high humidity leaves behind small lumps or color shifts. We offer guidance on proper handling (keep it dry, reseal containers after every use) and run batch studies on samples to ensure our powders remain stable for extended supply chains.

    Environmental and Supply Chain Pressures

    Globally, all chemical manufacturing faces pressure over environmental footprint—phosphate production is no exception. Our wastewater streams run through advanced neutralization and filtration to pull contaminants before water re-enters municipal systems. Solid byproduct recycling, energy use reduction, and careful management of phosphogypsum residues all play into ongoing work to lower resource use. Several technical staff now devote time to reducing energy input per tonne and closing all reagent loops. Regulatory authorities continue to look harder at each element of our operation, from CO2 emissions down to final packaging disposal.

    International sourcing of raw materials affects every step downstream. Geopolitical tensions, freight delays, and mine closures can suddenly throttle phosphate rock supply, pushing buyers toward alternative sources, typically at higher cost or inconsistent quality. Our procurement teams constantly qualify new suppliers, conduct independent assays, and stockpile strategic reserves when possible. These supply shocks translate into real-world issues: missed production, late delivery, and renegotiated pricing for loyal buyers. Open communication and sharing supply chain forecasts help customers plan better, reducing risk of ingredient shortages for essential food and feed manufacturing.

    We continually invest in plant modernization: energy-efficient reactors, automated process control, and on-line testing units lower labor effort and reduce sampling errors. All improvements feed back into increased plant reliability and consistent powder output. The benefit for end-users: fewer product withdrawals, more reliable formula performance, and steadier pricing over time.

    Ongoing Developments and Industry Trends

    Ongoing industry change now reaches down to even the most established materials. One area we watch: functional calcium additives for specialized health products and infant nutrition. Food and supplement manufacturers want ever-higher traceability, ensuring every mineral input meets allergy, non-animal, non-GMO, and ultra-low metal standards. Innovation in microencapsulation, ultra-fine milling, and combining calcium with vitamins or herbal actives now ties directly to our plant’s flexibility. We work alongside buyers experimenting with new beverage fortification or tailored nutrient release in animal feeds. Every plant tweak—altered precipitation rates, post-synthesis conditioning, nano-milling—brings new challenges in dust control, quality monitoring, and staff training.

    Tighter environmental codes force innovation at the plant. Reuse of process water, capture and treatment of off-gases, and full recycling of solid residues change production economics but assure regulators and the final buyers of minimized waste and cleaner processes. We invest not just for compliance, but to prove ongoing progress to buyers worldwide.

    One other change comes from buyers themselves. With growing demand for sustainable and local sourcing, smaller regional factories now compete by promising lower carbon footprints or tailored production runs. This puts new pressure on established plants: modernization, digital supply tracking, and transparent customer service all feature in long-term planning. Risk exposure in the phosphate value chain now includes cyberattacks, regulatory shifts, and logistics breakdowns. Our technical and managerial teams meet regularly to update protocols, audit vulnerabilities, and maintain robust supplier-buyer relationships.

    Working Closely with Customers for Future Solutions

    Feedback from our customers drives technical development. End users know their own lines best, and manufacturing partners rarely shy away from sharing what works and what requires improvement—from complaints about flowability or flavor to qualifications for infant food and pharmaceutical use. We listen, test, and adjust. This direct link means we get early warnings about new standards or emerging requirements, and adapt without extensive delays. Early-stage collaboration on product development, field trial support, and post-shipment troubleshooting all contribute to continuous product evolution.

    Looking ahead, we expect demands on quality, safety, and traceability to continue rising. A direct connection across the supplier-manufacturer-customer chain delivers a better experience for everyone relying on calcium hydrogen phosphate dihydrate as a critical raw material. Our experience confirms: investing in people, process, and plant delivers the most dependable powders, meets evolving regulations, and anticipates tomorrow’s market needs.