Vitamin B2

    • Product Name: Vitamin B2
    • Chemical Name (IUPAC): 7,8-dimethyl-10-[(2R,3R,4S)-2,3,4,5-tetrahydroxypentyl]benzo[g]pteridine-2,4-dione
    • CAS No.: 83-88-5
    • Chemical Formula: C17H20N4O6
    • Form/Physical State: Powder
    • Factroy Site: Lingwu, Yinchuan, Ningxia, China
    • Price Inquiry: sales2@liwei-chem.com
    • Manufacturer: Anhui Liwei Chemical Co.,Limited
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    Specifications

    HS Code

    501622

    Name Vitamin B2
    Alternative Name Riboflavin
    Chemical Formula C17H20N4O6
    Molecular Weight 376.37 g/mol
    Solubility Slightly soluble in water
    Appearance Yellow-orange crystalline powder
    Melting Point 280°C (decomposes)
    Biological Role Essential coenzyme in metabolism
    Daily Requirement Adult 1.1–1.3 mg
    Food Sources Eggs, milk, meat, green vegetables
    Deficiency Symptoms Sore throat, mouth cracks, skin disorders
    Stability Sensitive to light, stable to heat
    Absorption Site Small intestine
    Storage Primarily stored in liver, heart, and kidneys

    As an accredited Vitamin B2 factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Vitamin B2 is packaged in a sealed, amber glass bottle containing 100 grams of bright yellow powder, clearly labeled with safety information.
    Container Loading (20′ FCL) 20′ FCL for Vitamin B2: typically holds 13–16 metric tons, packed in drums or cartons, with moisture-proof and secure packaging.
    Shipping Vitamin B2 (Riboflavin) should be shipped in well-sealed, moisture-proof containers, protected from light and heat to maintain stability. It is not classified as hazardous for transport, but avoid exposure to strong oxidizers. Follow standard shipping guidelines for chemicals and include appropriate labeling and documentation for safe handling.
    Storage Vitamin B2 (Riboflavin) should be stored in a tightly closed container, protected from light, moisture, and heat. It should be kept at room temperature, ideally between 15°C and 30°C (59°F to 86°F), and away from incompatible substances. Proper storage ensures the vitamin maintains its potency and prevents degradation due to light or environmental exposure.
    Shelf Life Vitamin B2 (Riboflavin) has a shelf life of about 3 years when stored in a cool, dry, and dark place.
    Application of Vitamin B2

    Applications of Vitamin B2 in Industrial Manufacturing

    As a core nutritional additive and colorant precursor, Vitamin B2 (Riboflavin) plays a pivotal role in multiple industrial sectors. Our vertically integrated manufacturing supports consistent supply and batch traceability for advanced formulations across regulated downstream fields. Below, we detail segmented application routes based on real-world customer production and regulatory environments.

    1. Animal Nutrition Premixes and Feeds

    Major animal feed manufacturers worldwide use this ingredient to fortify compound premixes, meal feeds, and micro-nutrient blends for poultry, swine, cattle, and aquaculture. It actively supports metabolic growth and feed conversion efficiency, especially where raw grains show micronutrient deficiencies. Typical industrial use incorporates crystalline or spray-dried grade at controlled rates to meet species-specific nutritional programs and regionally compliant finished feed profiles.

    Industry compliance standards

    • FSANZ Standard 1.3.1 (Australia)
    • EU Regulation (EC) No 1831/2003 on feed additives
    • AAFCO Official Publication (USA)
    • ISO 22000 management for feed safety

    Typical usage ratio

    • Range: 1.5–6 mg/kg complete feed (species and production stage dependent)
    • Adjusts according to NRC requirements and local guidelines

    Downstream process integration

    • Premixing with trace minerals and vitamins at the micro-dosing stage
    • Direct blending into pelleting, extrusion, or liquid dosing lines
    • Sampling for post-blend vitamin recovery and assay

    Final product types

    • Broiler and laying hen feed
    • Dairy and beef cattle TMR
    • Swine concentrate premixes
    • Aquaculture diets for fish and shrimp

    2. Human Dietary Supplements and Functional Foods

    Global nutraceutical factories incorporate this raw material into direct-compression tablets, multivitamin capsules, effervescent beverages, and fortified snacks. Finished product manufacturers require precise compliance with pharmaceutical excipient standards and validated bioavailability. Continuous batch testing ensures identity, purity, and label claim accuracy within GRAS and Pharmacopoeial guidelines for finished retail lines distributed via pharmacy, F&B, or e-commerce channels.

    Industry compliance standards

    • USP–NF Monograph: Riboflavin
    • 21 CFR 182.8152 (USA: GRAS status)
    • EU Regulation (EC) No 1925/2006 on food fortification
    • China Food Additive Standard GB 14880

    Typical usage ratio

    • Range: 0.2–10 mg per daily supplement unit
    • Dose set per regional dietary reference intake tables and overage calculation for shelf-life loss

    Downstream process integration

    • Listed in pre-blend with micronized and granulated actives
    • Direct dry blending prior to granulation or tableting
    • HPLC in-process analysis for label claim validation

    Final product types

    • Vitamin complex tablets
    • Effervescent multivitamin powders
    • Ready-to-drink wellness beverages
    • Breakfast cereal fortification

    3. Pharmaceutical Bulk Formulations

    Regulated drug manufacturers use pharmaceutical-grade batches as active ingredients or co-factors in prescription preparations for deficiency prevention and disease management. Integration typically follows strict cGMP protocols, covering raw material validation, contaminant thresholds, and pharmaceutical stability documentation. Finished dosage forms demand compliant bioactive delivery reflected in compendial assay and impurity control methods.

    Industry compliance standards

    • USP–NF, EP, JP Monographs for Riboflavin
    • ICH Q7: Good Manufacturing Practice for APIs
    • WHO Model List of Essential Medicines
    • FDA DMF referencing and Type II Drug Master File

    Typical usage ratio

    • Single-ingredient: 5–20 mg per oral tablet or capsule
    • Multi-component formulas: adjusted per medical prescription, sometimes down to 1 mg/unit

    Downstream process integration

    • Weighing and verified batch entry into blending or granulation
    • Wet granulation or direct compression based on pre-formulation studies
    • Post-production stability studies under ICH conditions

    Final product types

    • Prescription vitamin B2 tablets
    • Injectable multi-vitamin ampoules
    • Oral liquids for pediatric and geriatric use
    • Hospital nutrition compound infusions

    4. Industrial Food & Beverage Colorants

    Food ingredient processors and beverage syrup factories employ this material as a yellow colorant (E101) for bakery, dairy, and liquid applications. Functional color stability and certified purity support safe food use. Downstream process teams carefully dose the ingredient to hit target hues while maintaining regulatory compliance with allowed additive limits for each region and application type.

    Industry compliance standards

    • EU Regulation (EC) No 1333/2008 (E101 food color)
    • FDA 21 CFR 73.450 (USA: color additive)
    • Codex Alimentarius STAN 192-1995
    • GB 2760: National Food Additive Standard, China

    Typical usage ratio

    • Bakery and dairy: 5–50 mg/kg product (based on desired yellow intensity and application regulations)
    • Beverages: 0.1–5 mg/L, adjusted for clarity and dosage efficacy

    Downstream process integration

    • Dry blending in premix for baked goods, or liquid addition during pasteurization
    • Dispersing in aqueous or emulsified bases via high-shear mixing
    • Batch validated through QC colorimeter or spectrophotometry

    Final product types

    • Industrial bread and bakery mixes
    • Processed cheese and dairy spreads
    • Sports drinks and vitamin waters
    • Flavored yogurt and dessert toppings

    5. Fermentation and Bioprocessing Substrate

    Biotechnology and fermentation plants introduce Vitamin B2 as an essential micronutrient in microbial growth media to optimize culturability and yield for select production strains. This application ensures robust starter culture propagation or specialty metabolite output. Raw material dosing is stringently controlled to align with patent-protected bioprocess recipes and downstream recovery protocols for consistent lot-to-lot reproducibility.

    Industry compliance standards

    • ISO 9001 and HACCP for biomanufacturing
    • USP Chapter <823> for cell culture and fermentation
    • Local environmental discharge standards (for bioprocess residues)

    Typical usage ratio

    • 0.01–0.1 mg/L in bacterial and yeast fermentation broths (subject to media design and microorganism requirements)
    • Increased up to 0.5 mg/L for high-density starter culture propagation

    Downstream process integration

    • Addition to sterile nutrient tanks prior to inoculation
    • Included as a defined ingredient in synthetic or semi-synthetic growth media
    • Charged to upstream process via in-line dosing systems

    Final product types

    • Probiotic culture concentrates
    • Enzyme production bulks
    • Bio-catalyst intermediates
    • Pharma and food fermentation starters

    Free Quote

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    Certification & Compliance
    More Introduction

    Vitamin B2 – A Manufacturer’s Eye on Quality and Application

    Introduction to Vitamin B2 in Production

    In a world where nutrition standards keep growing, the demand for well-made, reliable Vitamin B2 has never lost momentum. This ingredient goes beyond a commodity approach. After years turning raw materials into finished Vitamin B2 at scale, the lessons earn their weight: purity and consistency in the final product can be traced back to choices on our own factory floor. Consumers and formulators, from global supplement leaders to local feed mills, keep Vitamin B2 in their toolbox for its essential nutritional value. From the perspective of a manufacturer, every kilogram shipped carries not just a molecule, but a reputation built on batch-to-batch trust.

    Understanding Our Vitamin B2 – Model and Composition

    Our Vitamin B2, also known as riboflavin, comes in the familiar yellow-orange crystalline powder or as a precisely granulated feed grade, based on customer needs. The bulk of our clients request the crystalline form, owing to its solubility in water, bright color, and blending properties. This model gives versatility across human and animal nutrition, food fortification, and industrial formulations. The molecular formula C17H20N4O6 remains a textbook standard, but achieving pharmaceutical or food-grade riboflavin in practice means going beyond theoretical values. Each step in synthesis, purification, and drying becomes part of the story.

    Specifications – Real-World Experience

    Our production targets purity levels tested by high-performance liquid chromatography, consistently reaching above 98%, with strict internal thresholds for related impurities. Particle size distribution gets monitored constantly because the right mesh helps with flowability and homogeneity in mixing lines. Loss on drying matters too – operators know how a miscalibrated dryer can create headaches in bulk density and packaging. Color characteristics, often overlooked by those outside manufacturing, become a mark of careful crystallization. With Vitamin B2, that deep yellow communicates more than just aesthetic value; it signals successful finishing and minimal breakdown.

    Why Formulators Choose Our Riboflavin

    Reliability in ingredient quality matters most to those running tight production schedules. Consistency is not just a word for us — it reflects years working hand-in-hand with machinery, adjusting filtration and controlling every variable from fermentation to drying. End-users in the food, beverage, animal feed, and pharmaceutical fields bring strict specifications for purity, color, particle profile, and microbial load. Their audits keep us sharp, ensuring our product remains compliant with pharmacopoeial requirements or regional food safety codes. Missteps add costs by the ton, teaching us that a manufacturer’s vigilance must not waver.

    Key Uses in Various Industries

    Riboflavin supports everything from large-scale food fortification to targeted therapeutic supplements. Bakeries rely on it for bread enrichment, pushing public health goals in markets where micronutrient deficiencies persist. Dairy manufacturers use it to meet regulatory vitamin levels. Animal nutrition experts select our feed-grade model because livestock and poultry grow faster and healthier with vitamin-enriched diets. Producers of sports nutrition, tablets, capsules, and premixes take our crystalline powder because it disperses predictably and survives processing stresses that can destabilize inferior sources.

    Lessons from Decades in Manufacturing

    We have seen how sourcing choices affect the final product. Raw material variability, time-of-year changes in water quality, and even shifts in global fermentation feedstock prices directly touch our daily workflow. Riboflavin’s yellows and oranges define more than just a chemical – they are feedback from the largest reactors right down to the smallest QC batch sample. Once, years ago, a subtle shift in supplier grade nearly caused color drift during a routine audit, forcing a week-long review of standards. The batch released only after extensive rechecking, driving home the lesson: micronutrient manufacturing leaves no room for assumption.

    Differences from Other Vitamin B2 Products

    The world does not want copy-paste riboflavin. Our production focuses on maximizing purity and stability, minimizing odor and off-colors, and offering models for both feed and human applications. What separates our Vitamin B2 from cheaper, inconsistent alternatives is decades of process refinement, staff training, and plant investment. Some traders source from unknown origins. We scale batches from consistent fermentation strains, maintain rigorous environmental controls, and invest in in-house analytics. Every shipper of our crystalline Vitamin B2 carries traceable lot data, letting users track back through each stage of manufacturing and logistics.

    The difference becomes clear in formulation. Whether blending premixes, fortifying breakfast cereals, or producing livestock feed, our Vitamin B2 dissolves efficiently and resists caking or degradation. We do not shortcut on microbiological cleanliness, a point that is not universal in the industry. Customers with experience in tablet compression or high potency applications know how even small differences in the supplier’s manufacturing controls can impact tablet disintegration, taste, dispersibility, and shelf stability.

    Challenges in the Market and Our Approach

    Global supply chains have always faced unpredictable swings. A global fermentation shortage, regulatory tightening, or a spike in demand for preventive supplements can ripple through, squeezing the market. Only robust manufacturing infrastructure absorbs these shocks. We have witnessed how smaller players vanish from the market during price wars, unable to maintain GMP-compliant output at competitive costs. Larger, time-tested manufacturers scale operations sensibly, keep stocks ahead of demand, and maintain transparent communications with customers—even when market pressures make that uncomfortable.

    Consumers have become more aware of where their vitamins come from. Gone are the days when generic riboflavin on a label could satisfy market needs. Our factory accepts regular audits from multinational food firms, third-party verifiers, and even government agencies. The open-door approach builds trust throughout the value chain; only consistent results over years keep contracts steady. With Vitamin B2, as in many essential nutrients, all the recycled marketing talk fades quickly in the face of a raw batch certificate.

    Why Transparency and Traceability Matter

    After decades producing and distributing riboflavin, we have seen how traceability protects both suppliers and customers. Regulatory codes tighten every year. Be it human, pet, or livestock nutrition, authorities demand origin records, batch controls, and rapid recall protocols. The manufacturing side fits barcodes onto every lot, digital records track from reactor to warehouse. Knowing exactly where a specific batch originated and how it moved through production becomes the norm, not the exception. The days of back-of-envelope records or no-questions-asked reselling faded long ago.

    One memorable instance: an unexpected impurity peak during a chromatography scan. Instead of a recall, our traceability allowed isolation of just two suspect drums, with documented corrective steps and client notification within hours. These stories rarely reach the public eye, yet behind every drum of riboflavin sit lessons from experience, reinforced by every process improvement initiative. Safety and compliance do not arrive by chance; they take root in every floor meeting and every decision from procurement to packaging.

    Innovation, Sustainability, and Continuous Improvement

    Manufacturers in chemicals always walk a balance. High quality means process control, while market pressure constantly pushes for lower costs. Sustainable production emerges as a new frontier for Vitamin B2 as well. Consumers want assurance that their vitamins have not been manufactured at the expense of the environment. Our plant teams find value in recycling process water, optimizing fermentation media, and reducing waste across the board. Improved bacterial strains and controlled growth conditions bring yield up while keeping energy use in check. Every process tweak, lab bench experiment, or feedback from our engineering staff adds incremental progress and reduces resource use.

    Years spent monitoring energy use, managing effluent, and working with local regulators taught us clear lessons. Sustainability cannot be delegated to a public relations line; it must live in production metrics. We explore biological nutrient recovery techniques, invest in waste heat reuse, and curate supplier networks with eyes open to both compliance and reputation. The result is not just an environmental checkbox but a supply chain that customers can stand behind.

    End-User Experiences and Product Application

    Step inside a food formulation lab or a premix blending facility, and riboflavin shows its value. A batch of fortified bread fails color or homogeneity tests. Product managers quickly discover the difference between a dependable supply and an unknown blend. Our feedback loop with customers brings us close to their needs, informing adjustments in granule sizing, moisture levels, and even packaging formats. Some formulations require tight odor control or rapid solubility, leading us to collaborate directly with technical teams, offering lot samples, and adjusting processing parameters in real time.

    In animal feed plants, our feed-grade riboflavin often meets blending challenges introduced by complex premix matrices. Particle size and flow become more than tech specs—they define how much vitamin ends up active in the animal’s final diet. Downtime on a pelleting line due to poor flow can cost tens of thousands daily. Our plant teams stay on call to diagnose issues, provide technical backup, and, when necessary, dispatch staff for rapid troubleshooting. True manufacturing support goes far beyond a specification sheet.

    Quality Control – Lessons Learned Over Time

    Many outsiders see quality as a simple pass/fail gauge. In reality, it runs through every step of our operations. Raw material checks, in-process analytics, finished goods inspections—each provides data that drives improvement. Close attention to storage and shipping conditions makes a difference, especially across climates or unpredictable transport routes. Vitamin B2 may seem robust, but protection from light and humidity is non-negotiable. We receive reports from customers who switched to lower-grade sources only to find discolored or clumped vitamin powder after a few weeks, risking entire batches of premium product lines.

    Over the years, our teams developed integrated quality processes, inviting feedback from both the shop floor and downstream users. Instruments receive regular calibration. Results in laboratory notebooks align with in-plant metrics. This culture of continuous checking and open reporting roots itself deeply, far from the isolated, complacent approaches seen before. Customers bring higher expectations each year, and their standards raise the bar for us; the partnership between manufacturer and end-user never stops evolving.

    Addressing Challenges in Vitamin B2 Supply

    Uncontrollable events, such as global trade upheavals or sharp price swings in fermentation substrates, challenge even the most robust manufacturer. The only way to shield customers is by holding reserves, maintaining alternate sourcing pipelines, and sticking to ethical procurement. Competition nearly always tries to cut corners by pushing less stable or poorly documented riboflavin onto the market. We lose orders to these low-priced options at times, but experience shows nearly every buyer returns after facing the real-world problems of off-spec vitamins: failed QA, rejected lots, animal or consumer health risks, or lost confidence from their own clients.

    In extraordinary years, supply chain shocks can pressure raw material access or even disrupt secondary packaging materials. Our forward-planning teams run scenario analyses, schedule batch production months ahead, and flex output to demand surges. Partnerships with trusted freight providers prevent costly storage errors or spoilage. By keeping transparency around lead times, raw stock, and variables that affect cost, we help customers navigate uncertainty instead of leaving them in the dark. Resilience in the supply of Vitamin B2 reflects decades of knowing both the science and the realities of industrial commerce.

    Future Perspectives for Riboflavin Manufacturing

    Manufacturers see product cycles from a different vantage point than resellers. Changes in global food patterns, regulations on nutrient fortification, and breakthrough advances in fermentation science update our playbook year after year. Consumer interest in cleaner labels and certifications means our Vitamin B2 must regularly exceed old benchmarks in residual solvents, microbial profile, and environmental footprint. Our R&D teams keep up both with evolving regulatory protocols and frontier strain development, aiming for higher yields and cleaner extracts.

    Trends such as custom formulation and personalized nutrition stretch our processes as well. Some customers request specialist profiles—non-GMO status, allergen tracing, special certification for baby food or supplements, or ultra-low endotoxin levels. These are not burdens to us; they represent opportunities to further align our process with the most demanding applications. Feedback from nutritionists, veterinarians, food technologists, and end-users helps direct our upgrades. The market never sits still, and only by direct engagement do we stay ahead.

    Ethical Stewardship and Commitment to Safety

    Manufacturing Vitamin B2 puts safety up front every day. Our team includes operators trained not only in process skills but also in hazard recognition, environmental stewardship, and ethical sourcing. From batch records to lab notebooks, traceability and integrity run through our systems. This commitment builds trust with our industrial customers, auditors, inspectors, and, ultimately, the individual consuming a fortified product or the farmer raising healthier livestock.

    Regulatory shifts, whether driven by science or precaution, do not surprise us. Instead, we treat these as an expected part of doing business. Our safety group tracks global updates, implements regular staff training, and fosters a culture of accountability that goes beyond minimum compliance. Every incident, however minor, becomes a teachable moment: an overfill in a blender, a near-miss in a packaging line, or a change in microbial readings. None get swept under the rug. This mindset applies equally whether shipping a single drum or filling a full container headed for a major food conglomerate.

    In Summary – Riboflavin from a Manufacturer’s Perspective

    Vitamin B2 manufacturing demands far more than turning out powder on a schedule. Behind every bag shipped lies a continuous cycle of improvement, accountability, and customer engagement. The difference between good and outstanding riboflavin runs through every stage—from precise fermentation control and careful sourcing to rigorous analytics, ethical standards, and responsive technical support. Our product reflects not just a chemical structure but a history of choices, investments, and daily dedication by our factory teams.

    Customers trust us with their brands and their consumers’ well-being. That bond shapes our business philosophy as much as economic pressures. By cultivating transparency, consistently exceeding regulatory standards, and pushing for innovation and sustainability, we position our Vitamin B2 to meet today’s needs and tomorrow’s challenges. This approach defines who we are as a manufacturer, standing behind every granule, batch, and order of riboflavin that leaves our doors.